Model Proteins Studied by the Group
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Ribosomal Protein S6The ribosomal protein S6 is a small, 101 amino acid, protein from Thermus thermophilus, consisting of two α-helices packed on top of a four stranded β-sheet. The secondary structure elements are arranged in a primary topology that gives a feature of a split β-α-β protein, which makes it a part of a family of proteins with the same fold |
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Ribosomal Protein L23L23 from Thermus thermophilus is a small ribosomal protein (96 aminoacids) here used as a model protein when searching for site specific information about the transition state ensemble and the folding reaction. L23 consists of three α-helixes packed against a four stranded β-sheet in a saddle like manner creating a hydrophobic core. Strand 3 and 4 is connected by a long unstructured loop which together with one side of the protein surface consists of a large amount of positively charged residues, probably of importance being a ribosomal protein interacting with RNA. |
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Cu/Zn Superoxide DismutaseThe SOD1 gene in human encodes a cytosolic copper-zink (Cu/Zn) superoxide dismutase (SOD) responsible for the defence against harmful superoxide radicals. SOD is composed of two identical subunits, forming a stable homodimer. Over 100 mutations in SOD have been identified in patients having the neurodegenerative disease amyotrophic lateral sclerosis (ALS). |